4DUF

cytochrome P450 BM3h-2G9 MRI sensor bound to serotonin

Summary for 4DUF

Entry DOI	10.2210/pdb4duf/pdb
Related	4DSW 4DTW 4DTY 4DTZ 4DU2 4DUA 4DUB 4DUC 4DUD 4DUE
Descriptor	cytochrome P450 BM3 variant 2G9, PROTOPORPHYRIN IX CONTAINING FE, SEROTONIN, ... (4 entities in total)
Functional Keywords	cytochrome p450, mri contrast sensor, directed evolution, oxidoreductase
Biological source	Bacillus megaterium
Cellular location	Cytoplasm (By similarity): P14779
Total number of polymer chains	4
Total formula weight	218560.06
Authors	Brustad, E.M.,Lelyveld, V.S.,Snow, C.D.,Crook, N.,Martinez, F.M.,Scholl, T.J.,Jasanoff, A.,Arnold, F.H. (deposition date: 2012-02-21, release date: 2012-06-13, Last modification date: 2023-09-13)
Primary citation	Brustad, E.M.,Lelyveld, V.S.,Snow, C.D.,Crook, N.,Jung, S.T.,Martinez, F.M.,Scholl, T.J.,Jasanoff, A.,Arnold, F.H. Structure-guided directed evolution of highly selective p450-based magnetic resonance imaging sensors for dopamine and serotonin. J.Mol.Biol., 422:245-262, 2012 Cited by PubMed: 22659321 DOI: 10.1016/j.jmb.2012.05.029 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation