4DF6
Crystal Structure of the inhibitor NXL104 Covalent Adduct with TB B-lactamase
Summary for 4DF6
| Entry DOI | 10.2210/pdb4df6/pdb |
| Related | 3NY4 |
| Descriptor | Beta-lactamase, PHOSPHATE ION, (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, ... (4 entities in total) |
| Functional Keywords | penicillin binding protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Mycobacterium tuberculosis |
| Total number of polymer chains | 1 |
| Total formula weight | 28729.92 |
| Authors | Hazra, S.,Blanchard, J. (deposition date: 2012-01-23, release date: 2012-07-18, Last modification date: 2015-06-03) |
| Primary citation | Xu, H.,Hazra, S.,Blanchard, J.S. NXL104 irreversibly inhibits the {beta}-lactamase from Mycobacterium tuberculosis. Biochemistry, 51:4551-4557, 2012 Cited by PubMed: 22587688DOI: 10.1021/bi300508r PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
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