4DDY
CTX-M-9 class A beta-lactamase complexed with compound 10
Summary for 4DDY
| Entry DOI | 10.2210/pdb4ddy/pdb |
| Related | 3G2Y 3G2Z 3G30 3G31 3G32 3G35 4DDS 4DE0 4DE1 4DE2 4DE3 4DE5 |
| Descriptor | Beta-lactamase, N-[3-(1H-tetrazol-5-yl)phenyl]-3-(trifluoromethyl)benzamide, DIMETHYL SULFOXIDE, ... (4 entities in total) |
| Functional Keywords | ctx-m, molecular docking, fragment, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Escherichia coli |
| Total number of polymer chains | 2 |
| Total formula weight | 60144.54 |
| Authors | Nichols, D.A.,Chen, Y. (deposition date: 2012-01-19, release date: 2012-03-28, Last modification date: 2023-09-13) |
| Primary citation | Nichols, D.A.,Jaishankar, P.,Larson, W.,Smith, E.,Liu, G.,Beyrouthy, R.,Bonnet, R.,Renslo, A.R.,Chen, Y. Structure-Based Design of Potent and Ligand-Efficient Inhibitors of CTX-M Class A Beta-Lactamase J.Med.Chem., 55:2163-2172, 2012 Cited by PubMed: 22296601DOI: 10.1021/jm2014138 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.36 Å) |
Structure validation
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