4DDL
PDE10a Crystal Structure Complexed with Novel Inhibitor
Summary for 4DDL
Entry DOI | 10.2210/pdb4ddl/pdb |
Related | 2OUP |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, SULFATE ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase 10a, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q9Y233 |
Total number of polymer chains | 2 |
Total formula weight | 80326.79 |
Authors | |
Primary citation | Hu, E.,Kunz, R.K.,Rumfelt, S.,Chen, N.,Burli, R.,Li, C.,Andrews, K.L.,Zhang, J.,Chmait, S.,Kogan, J.,Lindstrom, M.,Hitchcock, S.A.,Treanor, J. Discovery of potent, selective, and metabolically stable 4-(pyridin-3-yl)cinnolines as novel phosphodiesterase 10A (PDE10A) inhibitors. Bioorg.Med.Chem.Lett., 22:2262-2265, 2012 Cited by PubMed: 22365755DOI: 10.1016/j.bmcl.2012.01.086 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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