4D2R
Human IGF in complex with a Dyrk1B inhibitor
Summary for 4D2R
Entry DOI | 10.2210/pdb4d2r/pdb |
Related | 4D2S |
Descriptor | INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR, CHLORIDE ION, N-{2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}-4-(1H-pyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine, ... (4 entities in total) |
Functional Keywords | transferase, kinase, inhibitor, oncology |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 35047.63 |
Authors | Debreczeni, J.E.,Kettle, J.G.,Ballard, P.,Bardelle, C.,Butterworth, S.,Colclough, N.,Critchlow, S.E.,Fairley, G.,Fillery, S.,Graham, M.A.,Goodwin, L.,Guichard, S.,Hudson, K.,Mahmood, A.,Vincent, J.,Ward, R.A.,Whittaker, D. (deposition date: 2014-05-12, release date: 2015-04-22, Last modification date: 2019-10-23) |
Primary citation | Kettle, J.G.,Ballard, P.,Bardelle, C.,Cockerill, M.,Colclough, N.,Critchlow, S.E.,Debreczeni, J.E.,Fairley, G.,Fillery, S.,Graham, M.A.,Goodwin, L.,Guichard, S.,Hudson, K.,Ward, R.A.,Whittaker, D. Discovery and Optimization of a Novel Series of Dyrk1B Kinase Inhibitors to Explore a Mek Resistance Hypothesis. J.Med.Chem., 58:2834-, 2015 Cited by PubMed: 25738750DOI: 10.1021/ACS.JMEDCHEM.5B00098 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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