4CX3
Structure of rat neuronal nitric oxide synthase M336V D597N mutant heme domain in complex with 4-METHYL-6-(((3R,4R)-4-((5-(PYRIDIN-2-YL) PENTYL)OXY)PYRROLIDIN-3-YL)METHYL)PYRIDIN-2-AMINE
Summary for 4CX3
Entry DOI | 10.2210/pdb4cx3/pdb |
Related | 4CWV 4CWW 4CWX 4CWY 4CWZ 4CX0 4CX1 4CX2 4CX4 4CX5 4CX6 4CX7 |
Descriptor | NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (8 entities in total) |
Functional Keywords | oxidoreductase, inhibitor complex |
Biological source | RATTUS NORVEGICUS (NORWAY RAT) |
Cellular location | Cell membrane, sarcolemma; Peripheral membrane protein (By similarity): P29476 |
Total number of polymer chains | 2 |
Total formula weight | 100351.09 |
Authors | Li, H.,Poulos, T.L. (deposition date: 2014-04-03, release date: 2014-08-13, Last modification date: 2024-05-08) |
Primary citation | Li, H.,Jamal, J.,Delker, S.L.,Plaza, C.,Ji, H.,Jing, Q.,Huang, H.,Kang, S.,Silverman, R.B.,Poulos, T.L. Mobility of a Conserved Tyrosine Residue Controls Isoform-Dependent Enzyme-Inhibitor Interactions in Nitric Oxide Synthases. Biochemistry, 53:5272-, 2014 Cited by PubMed: 25089924DOI: 10.1021/BI500561H PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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