4CVA

MPS1 kinase with 3-aminopyridin-2-one inhibitors

Summary for 4CVA

• Entry DOI: 10.2210/pdb4cva/pdb
• Related: 4CV8 4CV9
• Descriptor: DUAL SPECIFICITY PROTEIN KINASE TTK, N-(6-oxo-1,6-dihydro-3,4'-bipyridin-5-yl)-4-(piperidin-1-yl)benzamide, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: transferase, fragment, inhibitor
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 1
• Total formula weight: 36850.07

Authors

Fearon, D.,Bavetsias, V.,Bayliss, R.,Schmitt, J.,Westwood, I.M.,vanMontfort, R.L.M.,Jones, K. (deposition date: 2014-03-24, release date: 2015-04-08, Last modification date: 2023-12-20)

• Primary citation: Fearon, D.,Bavetsias, V.,Bayliss, R.,Schmitt, J.,Westwood, I.M.,Van Montfort, R.L.M.,Jones, K.; Protein Kinase Selectivity of a 3-Aminopyridin-2- One Based Fragment Library, Identification of 3-Amino-5-(Pyridin-4-Yl)Pyridin-2(1H)-One as a Novel Scaffold for Mps1 Inhibition; To be Published,

Experimental method

X-RAY DIFFRACTION (2.5 Å)