4CSY
E-selectin lectin, EGF-like and two SCR domains complexed with Sialyl Lewis X
Summary for 4CSY
Entry DOI | 10.2210/pdb4csy/pdb |
Related | 4CSS 4CST |
Descriptor | E-SELECTIN, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]methyl 2-acetamido-2-deoxy-beta-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | cell-adhesion, human lectin, c-type lectin, inflammation, leukocyte, sialyl lewis x, slex, protein conformation, ligand-induced conformational change, catch- bond, cell adhesion |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cell membrane ; Single-pass type I membrane protein: P16581 |
Total number of polymer chains | 2 |
Total formula weight | 67458.13 |
Authors | Preston, R.C.,Jakob, R.P.,Binder, F.P.C.,Sager, C.P.,Ernst, B.,Maier, T. (deposition date: 2014-03-11, release date: 2014-09-24, Last modification date: 2023-12-20) |
Primary citation | Preston, R.C.,Jakob, R.P.,Binder, F.P.,Sager, C.P.,Ernst, B.,Maier, T. E-Selectin Ligand Complexes Adopt an Extended High-Affinity Conformation. J.Mol.Cell.Biol., 8:62-, 2016 Cited by PubMed: 26117840DOI: 10.1093/JMCB/MJV046 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.41 Å) |
Structure validation
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