4CRL

Crystal structure of human CDK8-Cyclin C in complex with cortistatin A

Summary for 4CRL

• Entry DOI: 10.2210/pdb4crl/pdb
• Descriptor: CYCLIN-DEPENDENT KINASE 8, CYCLIN-C, CORTISTATIN A, ... (5 entities in total)
• Functional Keywords: transferase, cyclin-dependent kinase 8, cdk8, cyclin c, ccnc, cortistatin a, mediator kinase, mediator complex, super-enhancer, transcription
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 81288.58

Authors

Myers, A.G.,Shair, M.D. (deposition date: 2014-02-27, release date: 2015-09-23, Last modification date: 2023-12-20)

• Primary citation: Pelish, H.E.,Liau, B.B.,Nitulescu, I.I.,Tangpeerachaikul, A.,Poss, Z.C.,Da Silva, D.H.,Caruso, B.T.,Arefolov, A.,Fadeyi, O.,Christie, A.L.,Du, K.,Banka, D.,Schneider, E.V.,Jestel, A.,Zou, G.,Si, C.,Ebmeier, C.C.,Bronson, R.T.,Krivtsov, A.V.,Myers, A.G.,Kohl, N.E.,Kung, A.L.,Armstrong, S.A.,Lemieux, M.E.,Taatjes, D.J.,Shair, M.D.; Mediator Kinase Inhibition Further Activates Super-Enhancer- Associated Genes in Aml; Nature, 526:273-, 2015; PubMed: 26416749; DOI: 10.1038/NATURE14904

Experimental method

X-RAY DIFFRACTION (2.4 Å)