4CC9
Crystal structure of human SAMHD1 (amino acid residues 582-626) bound to Vpx isolated from sooty mangabey and human DCAF1 (amino acid residues 1058-1396)
Summary for 4CC9
Entry DOI | 10.2210/pdb4cc9/pdb |
Descriptor | PROTEIN VPRBP, PROTEIN VPX, DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1, ... (6 entities in total) |
Functional Keywords | protein binding, hiv, siv, retroviral restriction factor, retroviral accessory protein, ubiquitination, proteasomal degradation |
Biological source | HOMO SAPIENS (HUMAN) More |
Cellular location | Cytoplasm: Q9Y4B6 Virion: P19508 Nucleus : Q9Y3Z3 |
Total number of polymer chains | 3 |
Total formula weight | 63166.39 |
Authors | Schwefel, D.,Groom, H.C.T.,Boucherit, V.C.,Christodoulou, E.,Walker, P.A.,Stoye, J.P.,Bishop, K.N.,Taylor, I.A. (deposition date: 2013-10-19, release date: 2013-12-11, Last modification date: 2024-05-08) |
Primary citation | Schwefel, D.,Groom, H.C.T.,Boucherit, V.C.,Christodoulou, E.,Walker, P.A.,Stoye, J.P.,Bishop, K.N.,Taylor, I.A. Structural Basis of Lentiviral Subversion of a Cellular Protein Degradation Pathway. Nature, 505:234-, 2014 Cited by PubMed: 24336198DOI: 10.1038/NATURE12815 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.473 Å) |
Structure validation
Download full validation report