4CAE

Plasmodium vivax N-myristoyltransferase in complex with a benzothiophene inhibitor (compound 20b)

Summary for 4CAE

Entry DOI	10.2210/pdb4cae/pdb
Related	4CAF
Descriptor	GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, CHLORIDE ION, ... (8 entities in total)
Functional Keywords	transferase, myristoylation, malaria, inhibitor, benzothiophene
Biological source	PLASMODIUM VIVAX (MALARIA PARASITE P. VIVAX)
Total number of polymer chains	3
Total formula weight	139624.68
Authors	Rackham, M.D.,Brannigan, J.A.,Rangachari, K.,Wilkinson, A.J.,Holder, A.A.,Tate, E.W.,Leatherbarrow, R.J. (deposition date: 2013-10-08, release date: 2014-04-02, Last modification date: 2024-05-08)
Primary citation	Rackham, M.D.,Brannigan, J.A.,Rangachari, K.,Meister, S.,Wilkinson, A.J.,Holder, A.A.,Leatherbarrow, R.J.,Tate, E.W. Design and Synthesis of High Affinity Inhibitors of Plasmodium Falciparum and Plasmodium Vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent Lipophilicity (Lelp). J.Med.Chem., 57:2773-, 2014 Cited by PubMed: 24641010 DOI: 10.1021/JM500066B PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.46 Å)

Structure validation