4C4M

Crystal structure of the Sonic Hedgehog-chondroitin-4-sulphate complex

Summary for 4C4M

Entry DOI	10.2210/pdb4c4m/pdb
Related	4C4N
Descriptor	SONIC HEDGEHOG PROTEIN, beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose, ZINC ION, ... (6 entities in total)
Functional Keywords	signaling protein, hedgehog signalling, morphogens, heparan sulphate proteoglycans, glycosaminoglycans
Biological source	MUS MUSCULUS (HOUSE MOUSE)
Total number of polymer chains	1
Total formula weight	19909.40
Authors	Whalen, D.M.,Malinauskas, T.,Gilbert, R.J.C.,Siebold, C. (deposition date: 2013-09-05, release date: 2013-10-02, Last modification date: 2024-05-08)
Primary citation	Whalen, D.M.,Malinauskas, T.,Gilbert, R.J.C.,Siebold, C. Structural Insights Into Proteoglycan-Shaped Hedgehog Signaling. Proc.Natl.Acad.Sci.USA, 110:16420-, 2013 Cited by PubMed: 24062467 DOI: 10.1073/PNAS.1310097110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation