4BTU

Factor Xa in complex with the dual thrombin-FXa inhibitor 57.

Summary for 4BTU

Entry DOI	10.2210/pdb4btu/pdb
Related	4BTI 4BTT
Descriptor	COAGULATION FACTOR X LIGHT CHAIN, COAGULATION FACTOR X HEAVY CHAIN, CALCIUM ION, ... (5 entities in total)
Functional Keywords	hydrolase, sar107375, factor xa inhibitor, thrombin inhibitor, chlorothiophene p1 fragment, s3 subsite, microsomes stability, oral antithrombotic, dual inhibitor, iv antithrombotic
Biological source	HOMO SAPIENS (HUMAN) More
Total number of polymer chains	4
Total formula weight	79489.86
Authors	Meneyrol, J.,Follmann, M.,Lassalle, G.,Wehner, V.,Barre, G.,Rousseaux, T.,Altenburger, J.M.,Petit, F.,Bocskei, Z.,Stehlin-Gaon, C.,Schreuder, H.,Alet, N.,Herault, J.-P.,Millet, L.,Dol, F.,Hasbrand, C.,Schaeffer, P.,Sadoun, F.,Klieber, S.,Briot, C.,Bono, F.,Herbert, J.-M. (deposition date: 2013-06-19, release date: 2013-12-18, Last modification date: 2019-05-08)
Primary citation	Meneyrol, J.,Follmann, M.,Lassalle, G.,Wehner, V.,Barre, G.,Rousseaux, T.,Altenburger, J.,Petit, F.,Bocskei, Z.,Schreuder, H.,Alet, N.,Herault, J.,Millet, L.,Dol, F.,Florian, P.,Schaeffer, P.,Sadoun, F.,Klieber, S.,Briot, C.,Bono, F.,Herbert, J. 5-Chlorothiophene-2-Carboxylic Acid [(S)-2-[2-Methyl-3-(2-Oxopyrrolidin-1-Yl)Benzenesulfonylamino]-3-(4-Methylpiperazin-1-Yl)-3-Oxopropyl]Amide (Sar107375), a Selective and Potent Orally Active Dual Thrombin and Factor Xa Inhibitor. J.Med.Chem., 56:9441-, 2013 Cited by PubMed: 24175584 DOI: 10.1021/JM4005835 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.37 Å)

Structure validation