4BN5
Structure of human SIRT3 in complex with SRT1720 inhibitor
Summary for 4BN5
Entry DOI | 10.2210/pdb4bn5/pdb |
Related | 4BN4 |
Descriptor | NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, N-{2-[3-(piperazin-1-ylmethyl)imidazo[2,1-b][1,3]thiazol-6-yl]phenyl}quinoxaline-2-carboxamide, ... (5 entities in total) |
Functional Keywords | hydrolase, lysine deacetylase, adp ribose |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Mitochondrion matrix: Q9NTG7 |
Total number of polymer chains | 12 |
Total formula weight | 389773.66 |
Authors | Nguyen, G.T.T.,Schaefer, S.,Gertz, M.,Weyand, M.,Steegborn, C. (deposition date: 2013-05-13, release date: 2013-06-26, Last modification date: 2023-12-20) |
Primary citation | Nguyen, G.T.T.,Schaefer, S.,Gertz, M.,Weyand, M.,Steegborn, C. Structures of Human Sirtuin 3 Complexes with Adp-Ribose and with Carba-Nad+ and Srt1720: Binding Details and Inhibition Mechanism Acta Crystallogr.,Sect.D, 69:1423-, 2013 Cited by PubMed: 23897466DOI: 10.1107/S0907444913015448 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.25 Å) |
Structure validation
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