4BHW
Structural basis for autoinhibition of the acetyltransferase activity of p300
Summary for 4BHW
Entry DOI | 10.2210/pdb4bhw/pdb |
Descriptor | HISTONE ACETYLTRANSFERASE P300, ZINC ION, [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]methyl (3R,20R)-20-carbamoyl-3-hydroxy-2,2-dimethyl-4,8,14,22-tetraoxo-12-thia-5,9,15,21-tetraazatricos-1-yl dihydrogen diphosphate, ... (4 entities in total) |
Functional Keywords | transferase, bromodomain, phd domain, ring domain, hat domain, enhanceosome |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 136652.84 |
Authors | Delvecchio, M.,Gaucher, J.,Aguilar-Gurrieri, C.,Ortega, E.,Panne, D. (deposition date: 2013-04-08, release date: 2013-08-14, Last modification date: 2023-12-20) |
Primary citation | Delvecchio, M.,Gaucher, J.,Aguilar-Gurrieri, C.,Ortega, E.,Panne, D. Structure of the P300 Catalytic Core and Implications for Chromatin Targeting and Hat Regulation Nat.Struct.Mol.Biol., 20:1040-, 2013 Cited by PubMed: 23934153DOI: 10.1038/NSMB.2642 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.799 Å) |
Structure validation
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