4BGG
Crystal structure of the ACVR1 kinase in complex with LDN-213844
Summary for 4BGG
Entry DOI | 10.2210/pdb4bgg/pdb |
Descriptor | ACTIVIN RECEPTOR TYPE-1, 1-{4-[5-(3,4,5-trimethoxyphenyl)pyridin-3-yl]phenyl}piperazine, CITRATE ANION, ... (5 entities in total) |
Functional Keywords | transferase, inhibitor, bmp signalling |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Membrane; Single-pass type I membrane protein: Q04771 |
Total number of polymer chains | 4 |
Total formula weight | 141158.26 |
Authors | Sanvitale, C.,Canning, P.,Cooper, C.,Wang, Y.,Mohedas, A.H.,Choi, S.,Yu, P.B.,Cuny, G.D.,Nowak, R.,Coutandin, D.,Vollmar, M.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2013-03-26, release date: 2013-04-10, Last modification date: 2023-12-20) |
Primary citation | Mohedas, A.H.,Wang, Y.,Sanvitale, C.E.,Canning, P.,Choi, S.,Xing, X.,Bullock, A.N.,Cuny, G.D.,Yu, P.B. Structure-Activity Relationship of 3,5-Diaryl-2-Aminopyridine Alk2 Inhibitors Reveals Unaltered Binding Affinity for Fibrodysplasia Ossificans Progressiva Causing Mutants. J.Med.Chem., 57:7900-, 2014 Cited by PubMed: 25101911DOI: 10.1021/JM501177W PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.56 Å) |
Structure validation
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