4BFP

Crystal structure of human tankyrase 2 in complex with WIKI4

Summary for 4BFP

Entry DOI	10.2210/pdb4bfp/pdb
Descriptor	TANKYRASE-2, 2-[3-[[4-(4-methoxyphenyl)-5-pyridin-4-yl-1,2,4-triazol-3-yl]sulfanyl]propyl]benzo[de]isoquinoline-1,3-dione, SULFATE ION, ... (5 entities in total)
Functional Keywords	transferase, protein-ligand complex, diphtheria toxin like fold, adp-ribosylation, transferase-transferase inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	56157.78
Authors	Haikarainen, T.,Narwal, M.,Lehtio, L. (deposition date: 2013-03-21, release date: 2013-06-19, Last modification date: 2024-05-08)
Primary citation	Haikarainen, T.,Venkannagari, H.,Narwal, M.,Obaji, E.,Lee, H.,Nkizinkiko, Y.,Lehtio, L. Structural Basis and Selectivity of Tankyrase Inhibition by a Wnt Signaling Inhibitor Wiki4 Plos One, 8:65404-, 2013 Cited by PubMed: 23762361 DOI: 10.1371/JOURNAL.PONE.0065404 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation