4BD1
Neutron structure of a perdeuterated Toho-1 R274N R276N double mutant Beta-lactamase in complex with a fully deuterated boronic acid (BZB)
Summary for 4BD1
Entry DOI | 10.2210/pdb4bd1/pdb |
Related | 1BZA 1IYO 1IYP 1IYQ 1IYS 1WE4 2WYX 2XQZ 2XR0 4BD0 |
Descriptor | TOHO-1 BETA-LACTAMASE, BENZO[B]THIOPHENE-2-BORONIC ACID (3 entities in total) |
Functional Keywords | hydrolase, perdeuterated neutron structure, extended-spectrum beta lactamases, ctx- m-type esbls |
Biological source | ESCHERICHIA COLI BL21 |
Total number of polymer chains | 1 |
Total formula weight | 28282.73 |
Authors | Tomanicek, S.J.,Weiss, K.L.,Standaert, R.F.,Ostermann, A.,Schrader, T.E.,Ng, J.D.,Coates, L. (deposition date: 2012-10-04, release date: 2013-01-16, Last modification date: 2017-03-22) |
Primary citation | Tomanicek, S.J.,Standaert, R.F.,Weiss, K.L.,Ostermann, A.,Schrader, T.E.,Ng, J.D.,Coates, L. Neutron and X-Ray Crystal Structures of a Perdeuterated Enzyme Inhibitor Complex Reveal the Catalytic Proton Network of the Toho-1 Beta-Lactamase for the Acylation Reaction. J.Biol.Chem., 288:4715-, 2013 Cited by PubMed: 23255594DOI: 10.1074/JBC.M112.436238 PDB entries with the same primary citation |
Experimental method | NEUTRON DIFFRACTION (2.002 Å) |
Structure validation
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