4AT5

CRYSTAL STRUCTURE OF TRKB KINASE DOMAIN IN COMPLEX WITH GW2580

Summary for 4AT5

Entry DOI	10.2210/pdb4at5/pdb
Related	1HCF 1WWB 4ASZ 4AT3 4AT4 4F0I
Descriptor	BDNF/NT-3 GROWTH FACTORS RECEPTOR, 5-{3-methoxy-4-[(4-methoxybenzyl)oxy]benzyl}pyrimidine-2,4-diamine, GLYCEROL, ... (4 entities in total)
Functional Keywords	transferase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	34810.20
Authors	Bertrand, T.,Kothe, M.,Liu, J.,Dupuy, A.,Rak, A.,Berne, P.F.,Davis, S.,Gladysheva, T.,Valtre, C.,Crenne, J.Y.,Mathieu, M. (deposition date: 2012-05-03, release date: 2012-08-22, Last modification date: 2023-12-20)
Primary citation	Bertrand, T.,Kothe, M.,Liu, J.,Dupuy, A.,Rak, A.,Berne, P.F.,Davis, S.,Gladysheva, T.,Valtre, C.,Crenne, J.Y.,Mathieu, M. The Crystal Structures of Trka and Trkb Suggest Key Regions for Achieving Selective Inhibition. J.Mol.Biol., 423:439-, 2012 Cited by PubMed: 22902478 DOI: 10.1016/J.JMB.2012.08.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation