4A5Y
Intermediate state of human kinesin Eg5 in complex with Ispinesib
Summary for 4A5Y
Entry DOI | 10.2210/pdb4a5y/pdb |
Related | 1II6 1Q0B 1X88 1YRS 2FKY 2FL2 2FL6 2G1Q 2GM1 2UYI 2UYM 2WOG 2X2R 2X7C 2X7D 2X7E 2XAE 4A1Z 4A28 4A50 4A51 |
Descriptor | KINESIN-LIKE PROTEIN KIF11, ADENOSINE-5'-DIPHOSPHATE, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | motor protein, mitosis |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm : P52732 |
Total number of polymer chains | 3 |
Total formula weight | 126284.69 |
Authors | Kaan, H.Y.K.,Kozielski, F. (deposition date: 2011-10-29, release date: 2012-11-07, Last modification date: 2023-12-20) |
Primary citation | Kaan, H.Y.K.,Major, J.,Tkocz, K.,Kozielski, F.,Rosenfeld, S.S. "Snapshots" of Ispinesib-Induced Conformational Changes in the Mitotic Kinesin Eg5. J.Biol.Chem., 288:18588-, 2013 Cited by PubMed: 23658017DOI: 10.1074/JBC.M113.462648 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.45 Å) |
Structure validation
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