3ZO2
The Synthesis and Evaluation of Diazaspirocyclic Protein Kinase Inhibitors
Summary for 3ZO2
Entry DOI | 10.2210/pdb3zo2/pdb |
Related | 3ZO1 3ZO3 3ZO4 |
Descriptor | CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT ALPHA, CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA, 6-(2,9-Diazaspiro[5.5]undecan-9-yl)-9H-purine, ... (6 entities in total) |
Functional Keywords | transferase-inhibitor complex, transferase/inhibitor |
Biological source | BOS TAURUS (BOVINE) More |
Total number of polymer chains | 2 |
Total formula weight | 43798.69 |
Authors | Allen, C.E.,Chow, C.L.,Caldwell, J.J.,Westwood, I.M.,van Montfort, R.L.,Collins, I. (deposition date: 2013-02-20, release date: 2013-03-06, Last modification date: 2023-12-20) |
Primary citation | Allen, C.E.,Chow, C.L.,Caldwell, J.J.,Westwood, I.M.,van Montfort, R.L.,Collins, I. Synthesis and evaluation of heteroaryl substituted diazaspirocycles as scaffolds to probe the ATP-binding site of protein kinases. Bioorg. Med. Chem., 21:5707-5724, 2013 Cited by PubMed: 23920481DOI: 10.1016/j.bmc.2013.07.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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