3ZG2

Sterol 14 alpha-demethylase (CYP51) from Trypanosoma cruzi in complex with the pyridine inhibitor (S)-2-(4-chlorophenyl)-2-(pyridin-3-yl)-1- (4-(4-(trifluoromethyl)phenyl)piperazin-1-yl)ethanone (EPL-BS1246,UDO)

Summary for 3ZG2

Entry DOI	10.2210/pdb3zg2/pdb
Related	3ZG3
Descriptor	STEROL 14-ALPHA DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, (S)-2-(4-chlorophenyl)-2-pyridin-3-yl-1-[4-[4-(trifluoromethyl)phenyl]piperazin-1-yl]ethanone, ... (4 entities in total)
Functional Keywords	oxidoreductase, monooxygenase, sterol biosynthesis, eukaryotic membranes, cytochrome p450 fold, endoplasmic reticulum membrane, inhibitor
Biological source	TRYPANOSOMA CRUZI
Total number of polymer chains	1
Total formula weight	53629.28
Authors	Hargrove, T.Y.,Wawrzak, Z.,Keenan, M.,Chatelain, E.,Lepesheva, G.I. (deposition date: 2012-12-14, release date: 2013-09-25, Last modification date: 2023-12-20)
Primary citation	Hargrove, T.Y.,Wawrzak, Z.,Alexander, P.W.,Chaplin, J.H.,Keenan, M.,Charman, S.A.,Perez, C.J.,Waterman, M.R.,Chatelain, E.,Lepesheva, G.I. Complexes of Trypanosoma Cruzi Sterol 14Alpha-Demethylase (Cyp51) with Two Pyridine-Based Drug Candidates for Chagas Disease: Structural Basis for Pathogen-Selectivity J.Biol.Chem., 288:31602-, 2013 Cited by PubMed: 24047900 DOI: 10.1074/JBC.M113.497990 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation