3WRU

Crystal structure of the bacterial ribosomal decoding site in complex with synthetic aminoglycoside with F-HABA group

Summary for 3WRU

• Entry DOI: 10.2210/pdb3wru/pdb
• Descriptor: RNA (5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*GP*CP*CP*GP*GP*CP*GP*AP*AP*GP*UP*CP*GP*C)-3'), (2R,3R)-4-amino-N-[(1R,2S,3R,4R,5S)-5-amino-4-[(2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyranosyl)oxy]-3-{[3-O-(2,6-diamino-2,3,4,6-tetradeoxy-beta-L-threo-hexopyranosyl)-beta-D-ribofuranosyl]oxy}-2-hydroxycyclohexyl]-3-fluoro-2-hydroxybutanamide, POTASSIUM ION, ... (4 entities in total)
• Functional Keywords: ribosomal rna, aminoglycoside, rna-antibiotic complex, rna/antibiotic
• Total number of polymer chains: 2
• Total formula weight: 16119.43

Authors

Maianti, J.P.,Kanazawa, H.,Dozzo, P.,Feeney, L.A.,Armstrong, E.S.,Kondo, J.,Hanessian, S. (deposition date: 2014-02-27, release date: 2014-11-05, Last modification date: 2024-03-20)

• Primary citation: Maianti, J.P.,Kanazawa, H.,Dozzo, P.,Matias, R.D.,Feeney, L.A.,Armstrong, E.S.,Hildebrandt, D.J.,Kane, T.R.,Gliedt, M.J.,Goldblum, A.A.,Linsell, M.S.,Aggen, J.B.,Kondo, J.,Hanessian, S.; Toxicity Modulation, Resistance Enzyme Evasion, and A-Site X-ray Structure of Broad-Spectrum Antibacterial Neomycin Analogs; Acs Chem.Biol., 9:2067-2073, 2014; PubMed: 25019242; DOI: 10.1021/cb5003416

Experimental method

X-RAY DIFFRACTION (2.3 Å)