3WN4

Crystal structure of human TLR8 in complex with DS-877

Summary for 3WN4

Entry DOI	10.2210/pdb3wn4/pdb
Descriptor	Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(2-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
Functional Keywords	leucine rich repeat, rna, glycosylation, innate immunity, rna recognition, ssrnar, structure-based ligand design, tlr8-specific agonist, vaccine adjuvants, antiviral-antitumor drug binding, immune system
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	97150.45
Authors	Tanji, H.,Ohto, U.,Shimizu, T. (deposition date: 2013-12-02, release date: 2014-02-19, Last modification date: 2022-08-24)
Primary citation	Kokatla, H.P.,Sil, D.,Tanji, H.,Ohto, U.,Malladi, S.S.,Fox, L.M.,Shimizu, T.,David, S.A. Structure-based design of novel human Toll-like receptor 8 agonists. Chemmedchem, 9:719-723, 2014 Cited by PubMed: 24474703 DOI: 10.1002/cmdc.201300573 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.81 Å)

Structure validation