3WI6
Crystal structure of MAPKAP Kinase-2 (MK2) in complex with non-selective inhibitor
Summary for 3WI6
Entry DOI | 10.2210/pdb3wi6/pdb |
Related | 3a2c |
Descriptor | MAP kinase-activated protein kinase 2, N-[(3S)-piperidin-3-yl]-7,8-dihydro-6H-pyrazolo[1,5-a]pyrrolo[3,2-e]pyrimidin-5-amine (2 entities in total) |
Functional Keywords | gly-rich loop formed, atp-binding, kinase, nucleotide-binding, phosphoprotein, serine/threonine-protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P49137 |
Total number of polymer chains | 6 |
Total formula weight | 226677.92 |
Authors | Fujino, A.,Fukushima, K.,Kubota, T.,Matsumoto, Y.,Takimoto-Kamimura, M. (deposition date: 2013-09-06, release date: 2013-12-18, Last modification date: 2023-11-08) |
Primary citation | Fujino, A.,Fukushima, K.,Kubota, T.,Matsumoto, Y.,Takimoto-Kamimura, M. Structure of the beta-form of human MK2 in complex with the non-selective kinase inhibitor TEI-L03090 Acta Crystallogr.,Sect.F, 69:1344-1348, 2013 Cited by PubMed: 24316826DOI: 10.1107/S1744309113030534 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.99 Å) |
Structure validation
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