3WBD

Crystal structure of anti-polysialic acid antibody single chain Fv fragment (mAb735) complexed with octasialic acid

Summary for 3WBD

• Entry DOI: 10.2210/pdb3wbd/pdb
• Related: 1PLG
• Descriptor: single chain Fv fragment of mAb735, N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid, CITRATE ANION, ... (4 entities in total)
• Functional Keywords: beta-sandwich, immunoglobulin fold, single chain fv fragment, anti-polysialic acid, alpha2-8 linked polysialic acid, immune system
• Biological source: Mus musculus (mouse)
• Total number of polymer chains: 2
• Total formula weight: 54780.19

Authors

Nagae, M.,Ikeda, A.,Hanashima, S.,Kitajima, K.,Sato, C.,Yamaguchi, Y. (deposition date: 2013-05-14, release date: 2013-10-16, Last modification date: 2023-11-08)

• Primary citation: Nagae, M.,Ikeda, A.,Hane, M.,Hanashima, S.,Kitajima, K.,Sato, C.,Yamaguchi, Y.; Crystal structure of anti-polysialic acid antibody single chain Fv fragment complexed with octasialic acid: insight into the binding preference for polysialic acid.; J.Biol.Chem., 288:33784-33796, 2013; PubMed: 24100042; DOI: 10.1074/jbc.M113.496224

Experimental method

X-RAY DIFFRACTION (1.8 Å)