3VUC
Human renin in complex with compound 5
Summary for 3VUC
Entry DOI | 10.2210/pdb3vuc/pdb |
Related | 3VSX |
Descriptor | Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2R,4S,5S)-5-amino-6-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]-2-ethyl-4-hydroxy-N-[(1R,2S,3S,5S,7S)-5-hydroxytricyclo[3.3.1.1~3,7~]dec-2-yl]hexanamide, ... (4 entities in total) |
Functional Keywords | aspartyl protease, ras, hypertension, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 76098.74 |
Authors | Takahashi, M.,Matsui, Y.,Hanzawa, H. (deposition date: 2012-06-26, release date: 2013-05-15, Last modification date: 2023-11-08) |
Primary citation | Nakamura, Y.,Fujimoto, T.,Ogawa, Y.,Sugita, C.,Miyazaki, S.,Tamaki, K.,Takahashi, M.,Matsui, Y.,Nagayama, T.,Manabe, K.,Mizuno, M.,Masubuchi, N.,Chiba, K.,Nishi, T. Discovery of DS-8108b, a Novel Orally Bioavailable Renin Inhibitor. Acs Med.Chem.Lett., 3:754-758, 2012 Cited by PubMed: 24900544DOI: 10.1021/ml300168e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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