3VQH

Bromine SAD partially resolves multiple binding modes for PKA inhibitor H-89

Summary for 3VQH

• Entry DOI: 10.2210/pdb3vqh/pdb
• Related: 1YDT
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, N-[2-(4-BROMOCINNAMYLAMINO)ETHYL]-5-ISOQUINOLINE SULFONAMIDE, ... (5 entities in total)
• Functional Keywords: protein-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm. Isoform 2: Cell projection, cilium, flagellum: P17612
• Total number of polymer chains: 2
• Total formula weight: 43679.49

Authors

Pflug, A.,Johnson, K.A.,Engh, R.A. (deposition date: 2012-03-23, release date: 2012-08-15, Last modification date: 2023-11-08)

• Primary citation: Pflug, A.,Johnson, K.A.,Engh, R.A.; Anomalous dispersion analysis of inhibitor flexibility: a case study of the kinase inhibitor H-89; Acta Crystallogr.,Sect.F, 68:873-877, 2012; PubMed: 22869112; DOI: 10.1107/S1744309112028655

Experimental method

X-RAY DIFFRACTION (1.95 Å)