3VJC

Crystal structure of the human squalene synthase in complex with zaragozic acid A

Summary for 3VJC

Entry DOI	10.2210/pdb3vjc/pdb
Related	3VJ8 3VJ9 3VJA 3VJB 3VJD 3VJE
Descriptor	Squalene synthase, Zaragozic acid A, PHOSPHATE ION, ... (5 entities in total)
Functional Keywords	farnesyl-diphosphate farnesyltransferase, head-to-head synthases, cholesterol biosynthesis, oxidoreductase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268
Total number of polymer chains	6
Total formula weight	241456.64
Authors	Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Ko, T.P.,Wang, A.H.J. (deposition date: 2011-10-14, release date: 2012-04-11, Last modification date: 2023-11-08)
Primary citation	Liu, C.I.,Jeng, W.Y.,Chang, W.J.,Ko, T.P.,Wang, A.H.J. Binding modes of zaragozic acid A to human squalene synthase and staphylococcal dehydrosqualene synthase J.Biol.Chem., 287:18750-18757, 2012 Cited by PubMed: 22474324 DOI: 10.1074/jbc.M112.351254 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.89 Å)

Structure validation