3VHE

Crystal structure of human VEGFR2 kinase domain with a novel pyrrolopyrimidine inhibitor.

Summary for 3VHE

Entry DOI	10.2210/pdb3vhe/pdb
Descriptor	Vascular endothelial growth factor receptor 2, 1-{2-fluoro-4-[(5-methyl-5H-pyrrolo[3,2-d]pyrimidin-4-yl)oxy]phenyl}-3-[3-(trifluoromethyl)phenyl]urea (3 entities in total)
Functional Keywords	kinase domain, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P35968
Total number of polymer chains	1
Total formula weight	41291.26
Authors	Oguro, Y.,Miyamoto, N.,Okada, K.,Takagi, T.,Iwata, H.,Awazu, Y.,Miki, H.,Hori, A.,Kamiyama, K.,Imanura, S. (deposition date: 2011-08-24, release date: 2011-11-02, Last modification date: 2024-03-20)
Primary citation	Oguro, Y.,Miyamoto, N.,Okada, K.,Takagi, T.,Iwata, H.,Awazu, Y.,Miki, H.,Hori, A.,Kamiyama, K.,Imamura, S. Design, synthesis, and evaluation of 5-methyl-4-phenoxy-5H-pyrrolo[3,2-d]pyrimidine derivatives: novel VEGFR2 kinase inhibitors binding to inactive kinase conformation. Bioorg.Med.Chem., 18:7260-7273, 2010 Cited by PubMed: 20833055 DOI: 10.1016/j.bmc.2010.08.017 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.55 Å)

Structure validation