3VA4
Crystal structure of the mammalian MDC1 FHA domain complexed with CHK2 pThr68 peptide
Summary for 3VA4
Entry DOI | 10.2210/pdb3va4/pdb |
Related | 3VA1 |
Descriptor | Mediator of DNA damage checkpoint protein 1, Serine/threonine-protein kinase Chk2 (3 entities in total) |
Functional Keywords | cell cycle, fha domain, dna-damage, chk2 and mdc1 dimerization |
Biological source | Mus musculus More |
Cellular location | Nucleus: Q5PSV9 Isoform 2: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 9: Nucleus. Isoform 12: Nucleus. Nucleus, PML body: O96017 |
Total number of polymer chains | 3 |
Total formula weight | 30528.76 |
Authors | Wu, H.H.,Wu, P.Y.,Huang, K.F.,Kao, Y.Y.,Tsai, M.D. (deposition date: 2011-12-28, release date: 2012-02-01) |
Primary citation | Wu, H.H.,Wu, P.Y.,Huang, K.F.,Kao, Y.Y.,Tsai, M.D. Structural Delineation of MDC1-FHA Domain Binding with CHK2-pThr68. Biochemistry, 2012 Cited by PubMed: 22211259DOI: 10.1021/bi201709w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.54 Å) |
Structure validation
Download full validation report