3UW9
Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H4K8acK12ac)
Summary for 3UW9
Entry DOI | 10.2210/pdb3uw9/pdb |
Descriptor | Bromodomain-containing protein 4, histone 4 peptide (H4K8acK12ac) (3 entities in total) |
Functional Keywords | bromodomain, bromodomain containing protein 4, cap, hunk1, mcap, mitotic chromosome associated protein, peptide complex, structural genomics consortium, sgc, protein binding |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (By similarity): O60885 Nucleus: P62805 |
Total number of polymer chains | 6 |
Total formula weight | 62626.12 |
Authors | Filippakopoulos, P.,Felletar, I.,Picaud, S.,Keates, T.,Muniz, J.,Gileadi, O.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2011-12-01, release date: 2012-03-14, Last modification date: 2024-04-03) |
Primary citation | Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149:214-231, 2012 Cited by PubMed: 22464331DOI: 10.1016/j.cell.2012.02.013 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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