3UU1

Anthranilate phosphoribosyltransferase (trpD) from Mycobacterium tuberculosis (complex with inhibitor ACS142)

Summary for 3UU1

Entry DOI	10.2210/pdb3uu1/pdb
Related	2bpq 3QQS 3QR9 3R88
Descriptor	Anthranilate phosphoribosyltransferase, 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	anthranilate phosphoribosyltransferase, anthranilic acids, magnesium, tryptophan, magnesium binding phosphoribosyl pyrophosphate, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	4
Total formula weight	157616.61
Authors	Castell, A.,Short, F.L.,Lott, J.S. (deposition date: 2011-11-27, release date: 2012-12-12, Last modification date: 2023-09-13)
Primary citation	Castell, A.,Short, F.L.,Evans, G.L.,Cookson, T.V.,Bulloch, E.M.,Joseph, D.D.,Lee, C.E.,Parker, E.J.,Baker, E.N.,Lott, J.S. The Substrate Capture Mechanism of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Provides a Mode for Inhibition. Biochemistry, 52:1776-1787, 2013 Cited by PubMed: 23363292 DOI: 10.1021/bi301387m PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.82 Å)

Structure validation