3TZM
TGF-beta Receptor type 1 in complex with SB431542
Summary for 3TZM
| Entry DOI | 10.2210/pdb3tzm/pdb |
| Descriptor | TGF-beta receptor type-1, 4-[5-(1,3-benzodioxol-5-yl)-4-(pyridin-2-yl)-1H-imidazol-2-yl]benzamide (3 entities in total) |
| Functional Keywords | alk5, sb431542, kinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane; Single-pass type I membrane protein: P36897 |
| Total number of polymer chains | 1 |
| Total formula weight | 35612.94 |
| Authors | Ogunjimi, A.A.,Zeqiraj, E.,Ceccarelli, D.F.,Sicheri, F. (deposition date: 2011-09-27, release date: 2012-05-23, Last modification date: 2023-09-13) |
| Primary citation | Ogunjimi, A.A.,Zeqiraj, E.,Ceccarelli, D.F.,Sicheri, F.,Wrana, J.L.,David, L. Structural Basis for Specificity of TGFbeta Family Receptor Small Molecule Inhibitors Cell Signal, 24:476-483, 2012 Cited by PubMed: 21983015DOI: 10.1016/j.cellsig.2011.09.027 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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