3THR

Crystal structure of rat native liver Glycine N-methyltransferase complexed with 5-methyltetrahydrofolate monoglutamate

Summary for 3THR

Entry DOI	10.2210/pdb3thr/pdb
Related	2IDK 3THS
Descriptor	Glycine N-methyltransferase, 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, TRIS(HYDROXYETHYL)AMINOMETHANE, ... (4 entities in total)
Functional Keywords	glycine n-methyltransferase, gnmt, folate, methyltransferase, folate binding, liver cytosol, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Rattus norvegicus (brown rat,rat,rats)
Cellular location	Cytoplasm: P13255
Total number of polymer chains	4
Total formula weight	132274.95
Authors	Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.,Newcomer, M.E.,Wagner, C. (deposition date: 2011-08-19, release date: 2011-11-16, Last modification date: 2023-09-13)
Primary citation	Luka, Z.,Pakhomova, S.,Loukachevitch, L.V.,Newcomer, M.E.,Wagner, C. Differences in folate-protein interactions result in differing inhibition of native rat liver and recombinant glycine N-methyltransferase by 5-methyltetrahydrofolate. Biochim.Biophys.Acta, 1824:286-291, 2011 Cited by PubMed: 22037183 DOI: 10.1016/j.bbapap.2011.10.008 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation