3TE7

Quinone Oxidoreductase (NQ02) bound to the imidazoacridin-6-one 5a1

Summary for 3TE7

Entry DOI	10.2210/pdb3te7/pdb
Descriptor	Ribosyldihydronicotinamide dehydrogenase [quinone], ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ... (6 entities in total)
Functional Keywords	fad binding protein, oxidoreductase, fad, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P16083
Total number of polymer chains	2
Total formula weight	53744.04
Authors	Dunstan, M.S. (deposition date: 2011-08-12, release date: 2011-09-21, Last modification date: 2023-09-13)
Primary citation	Dunstan, M.S.,Barnes, J.,Humphries, M.,Whitehead, R.C.,Bryce, R.A.,Leys, D.,Stratford, I.J.,Nolan, K.A. Novel Inhibitors of NRH:Quinone Oxidoreductase 2 (NQO2): Crystal Structures, Biochemical Activity, and Intracellular Effects of Imidazoacridin-6-ones. J.Med.Chem., 54:6597-6611, 2011 Cited by PubMed: 21859103 DOI: 10.1021/jm200416e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation