3TAX

A Neutral Diphosphate Mimic Crosslinks the Active Site of Human O-GlcNAc Transferase

Summary for 3TAX

Entry DOI	10.2210/pdb3tax/pdb
Descriptor	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, Casein kinase II subunit alpha, URIDINE-5'-DIPHOSPHATE, ... (6 entities in total)
Functional Keywords	thiocarbamate crosslink, covalent inhibitor, gylcosyltransferase inhibitor, o-glcnac transferase, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm: O15294
Total number of polymer chains	4
Total formula weight	165998.77
Authors	Lazarus, M.B.,Jiang, J.,Pasquina, L.,Sliz, P.,Walker, S. (deposition date: 2011-08-04, release date: 2011-11-16, Last modification date: 2023-09-13)
Primary citation	Jiang, J.,Lazarus, M.B.,Pasquina, L.,Sliz, P.,Walker, S. A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase. Nat.Chem.Biol., 8:72-77, 2011 Cited by PubMed: 22082911 DOI: 10.1038/nchembio.711 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.88 Å)

Structure validation