3SRV

Crystal structure of spleen tyrosine kinase (SYK) in complex with a diaminopyrimidine carboxamide inhibitor

Summary for 3SRV

• Entry DOI: 10.2210/pdb3srv/pdb
• Descriptor: Tyrosine-protein kinase SYK, 2-{[(3R,4R)-3-aminotetrahydro-2H-pyran-4-yl]amino}-4-[(4-methylphenyl)amino]pyrimidine-5-carboxamide, GLYCEROL, ... (5 entities in total)
• Functional Keywords: sk363, syk, non-receptor tyrosine kinase, spleen tyrosine kinase, transferase, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 65297.18

Authors

Somers, D.O.,Neu, M. (deposition date: 2011-07-07, release date: 2011-09-21, Last modification date: 2024-04-03)

• Primary citation: Liddle, J.,Atkinson, F.L.,Barker, M.D.,Carter, P.S.,Curtis, N.R.,Davis, R.P.,Douault, C.,Dickson, M.C.,Elwes, D.,Garton, N.S.,Gray, M.,Hayhow, T.G.,Hobbs, C.I.,Jones, E.,Leach, S.,Leavens, K.,Lewis, H.D.,McCleary, S.,Neu, M.,Patel, V.K.,Preston, A.G.,Ramirez-Molina, C.,Shipley, T.J.,Skone, P.A.,Smithers, N.,Somers, D.O.,Walker, A.L.,Watson, R.J.,Weingarten, G.G.; Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor.; Bioorg.Med.Chem.Lett., 21:6188-6194, 2011; PubMed: 21903390; DOI: 10.1016/j.bmcl.2011.07.082

Experimental method

X-RAY DIFFRACTION (1.95 Å)