3SI7
The crystal structure of the NBD1 domain of the mouse CFTR protein, deltaF508 mutant
Summary for 3SI7
Entry DOI | 10.2210/pdb3si7/pdb |
Descriptor | Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | cystic fibrosis, atp-binding domain, hydrolase |
Biological source | Mus musculus (mouse) |
Cellular location | Early endosome membrane; Multi-pass membrane protein (By similarity): P26361 |
Total number of polymer chains | 4 |
Total formula weight | 130441.08 |
Authors | Brautigam, C.A.,Caspa, E.,Thomas, P.J. (deposition date: 2011-06-17, release date: 2012-02-01, Last modification date: 2024-02-28) |
Primary citation | Mendoza, J.L.,Schmidt, A.,Li, Q.,Nuvaga, E.,Barrett, T.,Bridges, R.J.,Feranchak, A.P.,Brautigam, C.A.,Thomas, P.J. Requirements for efficient correction of DeltaF508 CFTR revealed by analyses of evolved sequences Cell(Cambridge,Mass.), 148:164-174, 2012 Cited by PubMed: 22265409DOI: 10.1016/j.cell.2011.11.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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