3SG8

Crystal Structure of Aminoglycoside-2''-Phosphotransferase Type IVa Tobramycin Complex

Summary for 3SG8

• Entry DOI: 10.2210/pdb3sg8/pdb
• Descriptor: APH(2'')-Id, TOBRAMYCIN, CHLORIDE ION, ... (4 entities in total)
• Functional Keywords: antibiotic resistance enzyme, transferase, aminoglycoside, phosphorylation, transferase-antibiotic complex, transferase/antibiotic
• Biological source: Enterococcus casseliflavus
• Total number of polymer chains: 2
• Total formula weight: 72687.30

Authors

Shi, K.,Houston, D.R.,Berghuis, A.M. (deposition date: 2011-06-14, release date: 2011-06-29, Last modification date: 2024-02-28)

• Primary citation: Shi, K.,Houston, D.R.,Berghuis, A.M.; Crystal Structures of Antibiotic-Bound Complexes of Aminoglycoside 2''-Phosphotransferase IVa Highlight the Diversity in Substrate Binding Modes among Aminoglycoside Kinases.; Biochemistry, 50:6237-6244, 2011; PubMed: 21678960; DOI: 10.1021/bi200747f

Experimental method

X-RAY DIFFRACTION (1.8 Å)