3SFC
Structure-Based Optimization of Potent 4- and 6-Azaindole-3-Carboxamides as Renin Inhibitors
Summary for 3SFC
Entry DOI | 10.2210/pdb3sfc/pdb |
Related | 3OOT 3OQF 3OQK |
Descriptor | Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... (5 entities in total) |
Functional Keywords | renin human, aspartyl protease, renin inhibition, hypertension, beta barrel, pepsin-like protease, glycosylation, extracellular space, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P00797 |
Total number of polymer chains | 2 |
Total formula weight | 76906.60 |
Authors | Scheiper, B.,Matter, H.,Steinhagen, H.,Bocskei, Z.,Fleury, V.,McCort, G. (deposition date: 2011-06-13, release date: 2011-08-31, Last modification date: 2020-07-29) |
Primary citation | Scheiper, B.,Matter, H.,Steinhagen, H.,Bocskei, Z.,Fleury, V.,McCort, G. Structure-based optimization of potent 4- and 6-azaindole-3-carboxamides as renin inhibitors. Bioorg.Med.Chem.Lett., 21:5480-5486, 2011 Cited by PubMed: 21840218DOI: 10.1016/j.bmcl.2011.06.114 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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