3S7A
Human dihydrofolate reductase binary complex with PT684
Summary for 3S7A
Entry DOI | 10.2210/pdb3s7a/pdb |
Descriptor | Dihydrofolate reductase, SULFATE ION, 4-({5-[(2,4-diaminopteridin-6-yl)methyl]-5H-dibenzo[b,f]azepin-2-yl}oxy)butanoic acid, ... (4 entities in total) |
Functional Keywords | single polypeptide chain, reductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 22299.33 |
Authors | |
Primary citation | Cody, V.,Pace, J.,Nowak, J. Structural analysis of human dihydrofolate reductase as a binary complex with the potent and selective inhibitor 2,4-diamino-6-{2'-O-(3-carboxypropyl)oxydibenz[b,f]-azepin-5-yl}methylpteridine reveals an unusual binding mode. Acta Crystallogr.,Sect.D, 67:875-880, 2011 Cited by PubMed: 21931219DOI: 10.1107/S0907444911030071 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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