3S2V

Crystal Structure of the Ligand Binding Domain of GluK1 in Complex with an Antagonist (S)-1-(2'-Amino-2'-carboxyethyl)-3-[(2-carboxythien-3-yl)methyl]thieno[3,4-d]pyrimidin-2,4-dione at 2.5 A Resolution

Summary for 3S2V

• Entry DOI: 10.2210/pdb3s2v/pdb
• Related: 2F34
• Descriptor: Glutamate receptor, ionotropic kainate 1, (S)-1-(2'-AMINO-2'-CARBOXYETHYL)-3-[(2-CARBOXYTHIEN-3-YL)METHYL]THIENO[3,4-D]PYRIMIDIN-2,4-DIONE, SULFATE ION, ... (6 entities in total)
• Functional Keywords: antagonist, ionotropic glutamate receptor, membrane protein
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P22756
• Total number of polymer chains: 2
• Total formula weight: 59515.56

Authors

Venskutonyte, R.,Frydenvang, K.,Kastrup, J.S. (deposition date: 2011-05-17, release date: 2011-06-22, Last modification date: 2023-09-13)

• Primary citation: Venskutonyte, R.,Butini, S.,Coccone, S.S.,Gemma, S.,Brindisi, M.,Kumar, V.,Guarino, E.,Maramai, S.,Valenti, S.,Amir, A.,Valades, E.A.,Frydenvang, K.,Kastrup, J.S.,Novellino, E.,Campiani, G.,Pickering, D.S.; Selective kainate receptor (GluK1) ligands structurally based upon 1H-cyclopentapyrimidin-2,4(1H,3H)-dione: synthesis, molecular modeling, and pharmacological and biostructural characterization.; J.Med.Chem., 54:4793-4805, 2011; PubMed: 21619066; DOI: 10.1021/jm2004078

Experimental method

X-RAY DIFFRACTION (2.5 Å)