3S2A
Crystal structure of PI3K-gamma in complex with a quinoline inhibitor
Summary for 3S2A
Entry DOI | 10.2210/pdb3s2a/pdb |
Descriptor | Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION, N-{2-chloro-5-[4-(morpholin-4-yl)quinolin-6-yl]pyridin-3-yl}-4-fluorobenzenesulfonamide, ... (4 entities in total) |
Functional Keywords | p110-gamma, kinase, phosphotransfer, p101, p84, leukocytes, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 110611.20 |
Authors | Whittington, D.A.,Tang, J.,Yakowec, P. (deposition date: 2011-05-16, release date: 2011-06-08, Last modification date: 2023-09-13) |
Primary citation | Nishimura, N.,Siegmund, A.,Liu, L.,Yang, K.,Bryan, M.C.,Andrews, K.L.,Bo, Y.,Booker, S.K.,Caenepeel, S.,Freeman, D.,Liao, H.,McCarter, J.,Mullady, E.L.,San Miguel, T.,Subramanian, R.,Tamayo, N.,Wang, L.,Whittington, D.A.,Zalameda, L.,Zhang, N.,Hughes, P.E.,Norman, M.H. Phospshoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors: Discovery and Structure-Activity Relationships of a Series of Quinoline and Quinoxaline Derivatives. J.Med.Chem., 54:4735-4751, 2011 Cited by PubMed: 21612232DOI: 10.1021/jm200386s PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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