3RYW

Crystal structure of P. vivax geranylgeranyl diphosphate synthase complexed with BPH-811

Summary for 3RYW

Entry DOI	10.2210/pdb3ryw/pdb
Related	3CC9 3RBM
Descriptor	Farnesyl pyrophosphate synthase, {2-[5-(decyloxy)pyridin-3-yl]ethane-1,1-diyl}bis(phosphonic acid), MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	transferase, geranylgeranyl diphosphate synthase, bph-811
Biological source	Plasmodium vivax
Total number of polymer chains	4
Total formula weight	187232.42
Authors	No, J.H.,Liu, Y.-L.,Zhang, Y.,Oldfield, E. (deposition date: 2011-05-11, release date: 2012-05-23, Last modification date: 2023-09-13)
Primary citation	No, J.H.,de Macedo Dossin, F.,Zhang, Y.,Liu, Y.L.,Zhu, W.,Feng, X.,Yoo, J.A.,Lee, E.,Wang, K.,Hui, R.,Freitas-Junior, L.H.,Oldfield, E. Lipophilic analogs of zoledronate and risedronate inhibit Plasmodium geranylgeranyl diphosphate synthase (GGPPS) and exhibit potent antimalarial activity. Proc.Natl.Acad.Sci.USA, 109:4058-4063, 2012 Cited by PubMed: 22392982 DOI: 10.1073/pnas.1118215109 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation