3RVB

The structure of HCV NS3 helicase (Heli-80) bound with inhibitor ITMN-3479

Summary for 3RVB

• Entry DOI: 10.2210/pdb3rvb/pdb
• Descriptor: RNA helicase, {1-[(5-chloro-2-methyl-1-benzothiophen-3-yl)methyl]-6-(3,5-diaminophenyl)-1H-indol-3-yl}acetic acid, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: helicase, atp hydrolysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Hepatitis C virus (HCV)
• Cellular location: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663
• Total number of polymer chains: 1
• Total formula weight: 53370.77

Authors

Mather, O.,Cheng, R.,Schonfield, D.,Barker, J. (deposition date: 2011-05-06, release date: 2014-09-24, Last modification date: 2024-02-28)

• Primary citation: Mather, O.,Cheng, R.,Schonfield, D.,Barker, J.; The structure of HCV NS3 helicase with inhibitor ITMN-3479; To be Published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)