3RTP
Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration
Summary for 3RTP
Entry DOI | 10.2210/pdb3rtp/pdb |
Descriptor | Mitogen-activated protein kinase 10, N-[4-cyano-3-(1H-1,2,4-triazol-5-yl)thiophen-2-yl]-2-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)acetamide (3 entities in total) |
Functional Keywords | jnk inhibitors, pharmacokinetic properties, neurodegeneration, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P53779 |
Total number of polymer chains | 1 |
Total formula weight | 42248.85 |
Authors | Bowers, S.,Truong, A.P.,Neitz, R.J.,Hom, R.K.,Sealy, J.M.,Probst, G.D.,Quincy, Q.,Peterson, B.,Chan, W.,Galemmo Jr., R.A.,Konradi, A.W.,Sham, H.L.,Pan, H.,Lin, M.,Yao, N.,Artis, D.R.,Zhang, H.,Chen, L.,Dryer, M.,Samant, B.,Zmolek, W.,Wong, K.,Lorentzen, C.,Goldbach, E.,Tonn, G.,Quinn, K.P.,Sauer, J.,Wright, S.,Powell, K.,Ruslim, L.,Ren, Z.,Bard, F.,Yednock, T.A.,Griswold-Prenne, I. (deposition date: 2011-05-03, release date: 2013-05-08, Last modification date: 2024-02-28) |
Primary citation | Bowers, S.,Truong, A.P.,Jeffrey Neitz, R.,Hom, R.K.,Sealy, J.M.,Probst, G.D.,Quincy, D.,Peterson, B.,Chan, W.,Galemmo, R.A.,Konradi, A.W.,Sham, H.L.,Toth, G.,Pan, H.,Lin, M.,Yao, N.,Artis, D.R.,Zhang, H.,Chen, L.,Dryer, M.,Samant, B.,Zmolek, W.,Wong, K.,Lorentzen, C.,Goldbach, E.,Tonn, G.,Quinn, K.P.,Sauer, J.M.,Wright, S.,Powell, K.,Ruslim, L.,Ren, Z.,Bard, F.,Yednock, T.A.,Griswold-Prenner, I. Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration. Bioorg.Med.Chem.Lett., 21:5521-5527, 2011 Cited by PubMed: 21813278DOI: 10.1016/j.bmcl.2011.06.100 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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