3RQK
Structure of the neuronal nitric oxide synthase heme domain in complex with 4-methyl-6-{[(3R,4R)-4-(2-{[(1R,2S)-2-(3-methylphenyl)cyclopropyl]amino}ethoxy)pyrrolidin-3-yl]methyl}pyridin-2-amine and its isomer
Summary for 3RQK
Entry DOI | 10.2210/pdb3rqk/pdb |
Related | 3RQJ 3RQL 3RQM 3RQN 3RQO 3RQP |
Descriptor | Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total) |
Functional Keywords | oxidoreductase, enzyme-inhibitor complex, oxidoreductase-inhibitor complex, oxidoreductase/inhibitor |
Biological source | Rattus norvegicus (brown rat,rat,rats) |
Cellular location | Cell membrane, sarcolemma ; Peripheral membrane protein : P29476 |
Total number of polymer chains | 2 |
Total formula weight | 100285.07 |
Authors | Li, H.,Delker, S.L.,Poulos, T.L. (deposition date: 2011-04-28, release date: 2012-05-02, Last modification date: 2023-09-13) |
Primary citation | Li, H.,Xue, F.,Kraus, J.M.,Ji, H.,Labby, K.J.,Mataka, J.,Delker, S.L.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Cyclopropyl- and methyl-containing inhibitors of neuronal nitric oxide synthase. Bioorg.Med.Chem., 21:1333-1343, 2013 Cited by PubMed: 23352768DOI: 10.1016/j.bmc.2012.12.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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