3RQD
Ideal Thiolate-Zinc Coordination Geometry in Depsipeptide Binding to Histone Deacetylase 8
Summary for 3RQD
| Entry DOI | 10.2210/pdb3rqd/pdb |
| Related PRD ID | PRD_000785 |
| Descriptor | Histone deacetylase 8, Largazole, ZINC ION, ... (5 entities in total) |
| Functional Keywords | histone deacetylase, largazole, histone deacetylation, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) More |
| Cellular location | Nucleus: Q9BY41 |
| Total number of polymer chains | 4 |
| Total formula weight | 87852.62 |
| Authors | Cole, K.E.,Dowling, D.P.,Christianson, D.W. (deposition date: 2011-04-28, release date: 2011-08-24, Last modification date: 2023-11-15) |
| Primary citation | Cole, K.E.,Dowling, D.P.,Boone, M.A.,Phillips, A.J.,Christianson, D.W. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. J.Am.Chem.Soc., 133:12474-12477, 2011 Cited by PubMed: 21790156DOI: 10.1021/ja205972n PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.143 Å) |
Structure validation
Download full validation report
