3RCD

HER2 Kinase Domain Complexed with TAK-285

Summary for 3RCD

Entry DOI	10.2210/pdb3rcd/pdb
Related	3POZ 3PP0
Descriptor	Receptor tyrosine-protein kinase erbB-2, N-{2-[4-({3-chloro-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}-3-hydroxy-3-methylbutanamide (3 entities in total)
Functional Keywords	kinase domain, receptor, transferase, tyrosine-protein kinase, tyrosine kinase inhibitor, transferase-transferase inhibitor complex, anti-oncogene, cell cycle, disease, mutation, atp-binding, nucleotide-binding, glycoprotein, phosphoprotein, membrane, secreted, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cytoplasm. Isoform 3: Cytoplasm: P04626
Total number of polymer chains	4
Total formula weight	154011.96
Authors	Aertgeerts, K.,Skene, R.,Sogabe, S. (deposition date: 2011-03-30, release date: 2011-11-23, Last modification date: 2023-09-13)
Primary citation	Ishikawa, T.,Seto, M.,Banno, H.,Kawakita, Y.,Oorui, M.,Taniguchi, T.,Ohta, Y.,Tamura, T.,Nakayama, A.,Miki, H.,Kamiguchi, H.,Tanaka, T.,Habuka, N.,Sogabe, S.,Yano, J.,Aertgeerts, K.,Kamiyama, K. Design and Synthesis of Novel Human Epidermal Growth Factor Receptor 2 (HER2)/Epidermal Growth Factor Receptor (EGFR) Dual Inhibitors Bearing a Pyrrolo[3,2-d]pyrimidine Scaffold. J.Med.Chem., 54:8030-8050, 2011 Cited by PubMed: 22003817 DOI: 10.1021/jm2008634 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.21 Å)

Structure validation